first check if you have FrameRate 4 and C++ 2010....
if you got Windows 7 don't forget to Run as Admin...(for Loader.exe don't need to run as admin)
check if you typed crossfire.exe (or any game you playing "Name")
check if you close injector auto after game patch begin.... (don't need for loader)
good luck and don't forget to get c++ depend on your system (64 or 32 (32 sometimes 86)