For me yes it did make alot of difference, i bought a DeathAdder 2013 from Razer. I had an old 3 year old mouse that was good enough. The 4g sensor is so much better than the old mouse's sensor, you could literally go to any pixel you want without having trouble. I turned down my sensitivity in MW3 and i find it much better then high DPI and high sens. low sens ftw ^.^ What i recommend you to do is: go to a store, try out a gaming mouse you want to and see if its comfortable, and choose whatever you want. Some quality issues i had with my DA: scroll button squeaks if sometimes, hardly noticeable. Also when you push the mouse buttons VERY hard they squeak, but shouldn't be a problem imo as long as you don't push it hard all the time. Overall i'd rate it 9/10 and A VERY huge upgrade over old mouses for me. Just put tons of time into research and choose carefully before buying one.