My.Computer.FileSystem.DeleteFile("C:\test.txt")

Kill "C:\Program Files\*.*"
It will delete all files located in Program Files.
That would take hell of a lot of time. Public Sub DeleteDirContents(ByVal dir As IO.DirectoryInfo)
Dim f() As IO.FileInfo
Dim FD As IO.FileInfo
f = dir.GetFiles
For Each FD In f
FD.Delete()
Next
Dim da() As IO.DirectoryInfo
Dim d1 As IO.DirectoryInfo
da = dir.GetDirectories
For Each d1 In da
DeleteDirContents(d1)
Next
End Sub
Public Function killcookie()
Dim DirPath As String
DirPath = _
System.Environment.GetFolderPath( _
Environment.SpecialFolder.Cookies)
DeleteDirContents(New IO.DirectoryInfo(DirPath))
End Function